Pragmatic Clinical Trials

Evidence-based medicine relies on rigorous scientific studies to compare the effectiveness of treatments or procedures. The best clinical trials to inform medical decision making are large-scale, population-based studies, such as the 10-year, 11-state SPORT study that compared the effects of surgery vs. non-operative care for the three most common back conditions that lead people to seek surgery. The SPORT results have provided physicians and patients with new, objective information they can use to make their treatment decisions. TDI’s Pragmatic Clinical Trials Unit is dedicated to designing and facilitating similar trials that enhance patients’ ability to make a truly informed choice about their medical care.

The mission of TDI’s Pragmatic Clinical Trials unit is to develop, perform, and/or coordinate clinical trials that:

1) evaluate products or processes designed to aid patients’ informed choice;

2) assess patients’ preferences, values, and/or expectations and the role of these factors in treatment outcome;

3) seek to define or refine the key evidence base needed by patients making preference sensitive decisions; or

4) that deal with the national agenda of comparative effectiveness and how this information is transmitted to patients and their physicians.

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