Take a deeper look into all the publications produced by researchers at The Dartmouth Institute.

Weeks WB, Weinstein JN

2020 Dec 15;45(24):E1699-E1702doi: 10.1097/BRS.0000000000003717

: Level of Evidence: 3.

Spine (Phila Pa 1976)|2020 Dec 15

Pearson JL, Sharma E, Rui N, Halenar MJ, Johnson AL, Cummings KM, Hammad HT, Kaufman AR, Tworek C, Goniewicz ML, Kimmel HL, Tanski S, Compton WM, Day H, Ambrose BK, Bansal-Travers M, Silveira ML, Abrams D, Limpert J, Travers MJ, Borek N, Hyland AJ, Stanton CA

2020 Nov 2;3(11):e2015893doi: 10.1001/jamanetworkopen.2020.15893

The prevalence of electronic nicotine delivery systems (ENDS) use, including e-cigarettes, among US young adults (YAs) has raised questions about how these products may affect future tobacco and nicotine use among YAs. Given this prevalence and that young adulthood is a critical period for the establishment of tobacco and nicotine use, it is important to consider the association between ENDS use and cigarette smoking specifically in this age group.

JAMA Netw Open|2020 Nov 2

Davies L, Hoang JK

2020 Nov 19;pii: S2213-8587(20)30372-7. doi: 10.1016/S2213-8587(20)30372-7

Lancet Diabetes Endocrinol|2020 Nov 19

Albright RH, Rodela RJ, Nabili P, Gentchos CE, Summers NJ

2020 Aug 15;pii: S1067-2516(20)30294-5. doi: 10.1053/j.jfas.2020.08.007

Total ankle arthroplasty (TAA) is used as an alternative to ankle arthrodesis for adults with severe ankle arthritis. Numerous orthopedic centers have entered the healthcare market offering fast-tracked joint replacement protocols, meanwhile, TAA has been excluded from these joint centers, and is primarily performed in the inpatient setting. The purpose of this study is to examine short-term complications in the inpatient and outpatient settings following TAA using a systematic review and quantitative analysis. We considered all studies examining short-term complications following TAA performed in the inpatient versus outpatient setting occuring within 1 year of the index operation. We summarized data using a pooled relative risk and random effects model. A pooled sensitivity analysis was performed for studies with data on complication rates for inpatient or outpatient populations, which did not have a control group. The quality of included studies was assessed using the Cochrane risk of bias tool. Nine studies were included in the quantitative analysis, with 4 studies in the final meta-analysis. Subjects undergoing inpatient surgery experienced a 5-times higher risk of short-term complications compared to the outpatient group (risk ratio 5.27, 95% confidence interval 3.31, 8.42). Results did not change after sensitivity analysis (inpatient weighted mean complication rate: 9.62% vs outpatient weighted mean 5.02%, p value <.001). The overall level of evidence of included studies was level III, with a moderate to high risk of bias. Outpatient TAAs do not appear to pose excess complication risks compared to inpatient procedures, and may therefore be a reasonable addition to experienced centers that have established a fast-track outpatient total joint protocol.

J Foot Ankle Surg|2020 Aug 15

Soares-Weiser K, Lasserson T, Jorgensen KJ, Woloshin S, Bero L, Brown MD, Fischhoff B

2020 Nov 20;11:ED000149doi: 10.1002/14651858.ED000149

Cochrane Database Syst Rev|2020 Nov 20

House SA, Singh N, Wasserman JR, Kim Y, Ganduglia-Cazaban C, Goodman DC

2020 Nov 19;pii: hpeds.2020-000687. doi: 10.1542/hpeds.2020-000687

The success of neonatal intensive care in improving outcomes for critically ill neonates led to rapid growth of NICU use in the United States, despite a relatively stable birth cohort. Less is known about NICU use among late-preterm and term infants, although recent studies have observed wide variation in their care patterns. In this study, we measure special care days (SCDs) (intermediate or intensive), length of stay, and readmission rates among low-risk neonates across regions within 2 states.

Hosp Pediatr|2020 Nov 19

Engel J, Foster T

2020 Nov 16;pii: S0002-9378(20)31310-7. doi: 10.1016/j.ajog.2020.11.014

Am J Obstet Gynecol|2020 Nov 16

Petersen CL, Chen JQ, Salas LA, Christensen BC

2020 Nov 18;12(1):177doi: 10.1186/s13148-020-00972-9

Multiple studies have related psychiatric disorders and immune alterations. Panic disorder (PD) has been linked with changes in leukocytes distributions in several small studies using different methods for immune characterization. Additionally, alterations in the methylation of repetitive DNA elements, such as LINE-1, have been associated with mental disorders. Here, we use peripheral blood DNA methylation data from two studies and an updated DNA methylation deconvolution library to investigate the relation of leukocyte proportions and methylation status of repetitive elements in 133 patients with panic disorder compared with 118 controls.

Clin Epigenetics|2020 Nov 18

Scalia P, Barr PJ, O'Neill C, Crealey GE, Bagley PJ, Blunt HB, Elwyn G

2020 Nov 16;10(11):e036834doi: 10.1136/bmjopen-2020-036834

To update a previous systematic review to determine if patient decision aid (PDA) interventions generate savings in healthcare settings, and if so, from which perspective (ie, patient, organisation providing care, society).

BMJ Open|2020 Nov 16

Abraham WT, Psotka MA, Fiuzat M, Filippatos G, Lindenfeld J, Mehran R, Ambardekar AV, Carson PE, Jacob R, Januzzi JL Jr, Konstam MA, Krucoff MW, Lewis EF, Piccini JP, Solomon SD, Stockbridge N, Teerlink JR, Unger EF, Zeitler EP, Anker SD, O'Connor CM

2020 Nov 10;pii: S2213-1779(20)30568-0. doi: 10.1016/j.jchf.2020.10.002

The Heart Failure Academic Research Consortium is a partnership between the Heart Failure Collaboratory (HFC) and Academic Research Consortium (ARC), comprised of leading heart failure (HF) academic research investigators, patients, United States (US) Food and Drug Administration representatives, and industry members from the US and Europe. A series of meetings were convened to establish definitions and key concepts for the evaluation of HF therapies including optimal medical and device background therapy, clinical trial design elements and statistical concepts, and study endpoints. This manuscript summarizes the expert panel discussions as consensus recommendations focused on populations and endpoint definitions; it is not exhaustive or restrictive, but designed to stimulate HF clinical trial innovation.

JACC Heart Fail|2020 Nov 10


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