Publications

Take a deeper look into all the publications produced by researchers at The Dartmouth Institute.

Chen AY, Davies L

2019 Apr 23;doi: 10.1002/cncr.32124

Cancer|2019 Apr 23

Zhao Y, Schaafsma E, Cheng C

2018 Oct;11:57-64doi: 10.1016/j.coisb.2018.08.010

Large-scale genomic data have been utilized to generate unprecedented biological findings and new hypotheses. To delineate functional elements in the human genome, the Encyclopedia of DNA Elements (ENCODE) project has generated an enormous amount of genomic data, yielding around 7,000 data profiles in different cell and tissue types. In this article, we reviewed the systematic analyses that have integrated ENCODE data with other data sources to reveal new biological insights, ranging from human genome annotation to the identification of new candidate drugs. These analyses demonstrate the critical impact of ENCODE data on basic biology and translational research.

Curr Opin Syst Biol|2018 Oct

Rees CA, Bao R, Zegans ME, Cramer RA

2019 Apr 22;pii: AAC.02505-18. doi: 10.1128/AAC.02505-18

The activities of two antifungal drugs in combination with four non-antifungal ophthalmic agents were evaluated using a micro-broth dilution method and a collection of eight ocular isolates that exhibited resistance to both natamycin (MICs: 14-32 μg/mL) and voriconazole (4->128 μg/mL). Synergistic interactions were observed for natamycin with 5-fluorouracil (FICIs: 0.34-0.61) and natamycin with timolol (0.41-0.52). Synergistic or indifferent interactions were observed for natamycin with EDTA (0.38-1.00), natamycin with dorzolamide (0.53-1.00), voriconazole with EDTA (0.38-1.00), voriconazole with timolol (0.39-0.94), and voriconazole with 5-fluorouracil (0.53-0.75). Taken together, these data suggest commonly used ophthalmic agents enhance the activity of antifungal drugs against drug recalcitrant ocular fungal pathogens.

Antimicrob Agents Chemother|2019 Apr 22

Hung RJ, Spitz MR, Houlston RS, Schwartz AG, Field JK, Ying J, Li Y, Han Y, Ji X, Chen W, Wu X, Gorlov IP, Na J, de Andrade M, Liu G, Brhane Y, Diao N, Wenzlaff A, Davies MPA, Liloglou T, Timofeeva M, Muley T, Rennert H, Saliba W, Ryan BM, Bowman E, Barros-Dios JM, Pérez-Ríos M, Morgenstern H, Zie...

2019 Apr 19;pii: S1556-0864(19)30289-8. doi: 10.1016/j.jtho.2019.04.008

Inherited susceptibility to lung cancer risk in never smokers is poorly understood. The major reason for this gap in knowledge is that this disease is relatively uncommon (except in Asians), making it difficult to assemble an adequate study sample. In this study we conducted a genome-wide association study (GWAS) on the largest, to date, set of European-descent never smokers with lung cancer.

J Thorac Oncol|2019 Apr 19

Zacharias N, Wang GJ, Sedrakyan A, Columbo J, Boyle JR, Goodney PP

2019 Apr 19;pii: S0890-5096(19)30236-5. doi: 10.1016/j.avsg.2019.02.010

The use of fenestrated endovascular devices for repair of complex aortic aneurysms has increased to nearly 5,000 implantations annually in Medicare patients in the United States in recent years. Given that nearly all aspects of treatment for minimally invasive aortic intervention rely on medical devices to better care for patients with vascular disease, a clear understanding how new and innovative technology evolves over the life cycle of a medical device is an essential skill set for cardiovascular physicians. Despite the need for this understanding, there is no standard framework upon which cardiovascular physicians, regulators, and patients can rely to better understand the evolution of evidence from product inception through adoption and long-term effectiveness evaluation. As the above devices are increasingly and broadly used, the need of a formal framework for regulation and device approval has emerged. The goal of this review is to describe the Idea, Development, Exploration, Assessment, Long-term Study Framework for Devices (IDEAL-D). This framework is a model developed recently by an international panel of experts dedicated to better understanding the data steps necessary to bring a device from idea to routine practice to marketing, approval and monitoring. In this review, we use the example of fenestrated endovascular aortic devices to illustrate the IDEAL-D framework, and how it can help cardiovascular physicians improve their understanding of new technology, and the evidence which surrounds it from inception to long-term use.

Ann Vasc Surg|2019 Apr 19

Dwiel LL, Khokhar JY, Connerney MA, Green AI, Doucette WT

2019 Apr 22;15(4):e1006838doi: 10.1371/journal.pcbi.1006838

The ventral striatum (VS) is a central node within a distributed network that controls appetitive behavior, and neuromodulation of the VS has demonstrated therapeutic potential for appetitive disorders. Local field potential (LFP) oscillations recorded from deep brain stimulation (DBS) electrodes within the VS are a pragmatic source of neural systems-level information about appetitive behavior that could be used in responsive neuromodulation systems. Here, we recorded LFPs from the bilateral nucleus accumbens core and shell (subregions of the VS) during limited access to palatable food across varying conditions of hunger and food palatability in male rats. We used standard statistical methods (logistic regression) as well as the machine learning algorithm lasso to predict aspects of feeding behavior using VS LFPs. We were able to predict the amount of food eaten, the increase in consumption following food deprivation, and the type of food eaten. Further, we were able to predict whether the initiation of feeding was imminent up to 42.5 seconds before feeding began and classify current behavior as either feeding or not-feeding. In classifying feeding behavior, we found an optimal balance between model complexity and performance with models using 3 LFP features primarily from the alpha and high gamma frequencies. As shown here, unbiased methods can identify systems-level neural activity linked to domains of mental illness with potential application to the development and personalization of novel treatments.

PLoS Comput Biol|2019 Apr 22

Keating NL, O'Malley AJ, Onnela JP, Gray SW, Landon BE

2019 Apr 18;doi: 10.1097/MLR.0000000000001124

The intensity of end-of-life care varies substantially both within and between areas. Differing practice patterns of individual physicians are likely influenced by their peers.

Med Care|2019 Apr 18

Colla CH, Lewis VA, Stachowski C, Usadi B, Gottlieb DJ, Bynum JPW

2019 Apr 18;doi: 10.1097/MLR.0000000000001121

To examine changes in more and less discretionary condition-specific postacute care use (skilled nursing, inpatient rehabilitation, home health) associated with Medicare accountable care organization (ACO) implementation.

Med Care|2019 Apr 18

Shacklett BL, Blanco J, Hightow-Weidman L, Mgodi N, Alcami J, Buchbinder S, Chirenje M, Dabee S, Diallo M, Dumchev K, Herrera C, Levy ME, Martin-Gayo E, Makoah NA, Mitchell KM, Mugwanya K, Reddy K, Rodríguez ML, Rodriguez-Garcia M, Shover CL, Shrivastava T, Tomaras GD, Van Diepen M, Walia M, Warren...

2019 Apr 22;doi: 10.1089/AID.2019.0074

The HIV Research for Prevention (HIVR4P) conference is dedicated to advancing HIV prevention research, responding to a growing consensus that effective and durable prevention will require a combination of approaches as well as unprecedented collaboration among scientists, practitioners and community workers from different fields and geographic areas. The conference theme in 2018, "From Research to Impact", acknowledged an increasing focus on translation of promising research findings into practical, accessible and affordable HIV prevention options for those who need them worldwide. HIVR4P 2018 was held in Madrid, Spain, on 21-25 October, with over 1,400 participants from 52 countries around the globe, representing all aspects of HIV prevention research and implementation. The program included 137 oral and 610 poster presentations. This paper presents a brief summary of highlights from the conference. More detailed information, complete abstracts as well as webcasts and daily Rapporteur summaries may be found on the conference website at hivr4p.org.

AIDS Res Hum Retroviruses|2019 Apr 22

Coker MO, Hoen AG, Dade E, Lundgren S, Li Z, Wong AD, Zens MS, Palys TJ, Morrison HG, Sogin ML, Baker ER, Karagas MR, Madan JC

2019 Apr 21;doi: 10.1111/1471-0528.15799

To evaluate the potential impact of intrapartum antibiotics, and their specific classes, on the infant gut microbiota in the first year of life.

BJOG|2019 Apr 21

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